The Chelsea goalkeeper did not return for the second half of the Blues’ 2-1 loss after sustaining a knock in trying
Kepa Arrizabalaga replaced Mendy for the start of the second half at Villa Park.
A penalty from Anwar El Ghazi shortly into the second-half put Villa 2-0 ahead against Thomas Tuchel’s side before Ben Chilwell pulled a goal back for the visitors.
Despite the defeat on the final day of the league campaign, Chelsea finished fourth in the league – a point ahead of Leicester after the Foxes were beaten 4-2 by Tottenham at the King Power Stadium.
Chelsea face Premier League champions Manchester City in the Champions League final in Porto on Saturday.